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ESHG | Single-cell transcriptomic atlas of macaque and its application to study COVID-19
Stopping COVID-19 is a priority worldwide. Understanding which cell types are targeted by SARS-CoV-2 virus, whether interspecies differences exist, and how variations in cell state influence viral entry is fundamental for accelerating therapeutic and preventative approaches. The endeavor profiled the transcriptome at single-cell resolution of nine tissues from a Macaca fascicularis monkey. The work constitutes a unique resource for understanding SARS-CoV-2 pathophysiology in two phylogenetically close species, which might guide in the development of effective treatments in humans.
Dr Miguel Esteban
Professor, Guangzhou Institutes of Biomedicine and Health (Chinese Academy of Sciences)
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