COVID-19 has caused a major epidemic worldwide. However, much is yet to be known about the epidemiology and evolution of the virus. One reason is that the challenges underneath sequencing HCoV-19 directly from clinical samples have not been completely tackled. BGI researchers completed the first work systematically investigating inter- and intra-individual variations of HCoV-19 using amplicon and capture-based whole-genome sequencing, as well as the first comparative study among different approaches. In the webinar, Dr. Minfeng Xiao, associate Investigator of BGI Research, will illustrate the application of amplicon and hybrid capture (capture)-based sequencing, as well as metatranscriptomic (meta) sequencing in retrieving complete genomes, inter-individual and intra-individual variations of HCoV-19 from clinical samples covering a range of sample types and viral load.