MGI gene sequencing company

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ZTRON Appliance
The ZTRON Appliance is a data platform which is designed by MGI for the high-throughput sequencers. It integrates laboratory information management system (LIMS), bioinformatics accelerator and high-performance genetic data storage.

ZTRON Appliance can be used directly in the laboratory or in the traditional data centers. It can be deployed independently and scaled out easily.

Safe and reliable, it complies with GDPR regulations and reduces IT maintenance costs.

ZTRON Appliance includes two standard models, it also supports customization and expansion.
  ZTRON Lite- recommmended for DNBSEQ-T7
  ZTRON Pro- recommmended for DNBSEQ-T10
  Customized genomics data center

Product Highlights

High Performance
Analysis speed 60 times faster
Delivery capacity 2 times faster
Large file storage acceleration

High Security
Offline deployment
Standalone network
GDPR compliance

High Intelligence
Automated process
Flexible expansion
Bioinformatics with deep learning

High Availability
Redundant protection
Software fault tolerance
No single point failure

High Cost-effectiveness
Save occupied space
Reduce IT maintenance costs
Reduce storage by compression
Product Features
1 DNBSEQ Max-Capacity Sequencing
High performance computing cluster
Embedded GPU+FPGA accelerators
Automated analysis, multi-task scheduling
CPU+GPU+FPGA heterogeneous algorithms
ZTRON Pro converts the CAL files generated
by sequencers into FASTQ files (WFQ pipeline),
or uses FASTQ files as input, after mapping
and mutation detection, outputs BAM and
VCF/gVCF files (WGS/WES pipeline).
WFQ speed for DNBSEQ-T7 PE150(~2T data per flowcell)

~1hour

~2hours/RUN(4 flowcells)
WFQ speed for DNBSEQ-T10x4RS PE100(~14T data per flowcell)

~6hour

~24hours/RUN(8 flowcells)
ZTRON Pro integrates ZBOLT heterogeneous
computing technology, which greatly improves
the speed of WGS/WES secondary analysis.
WGS analysis(~6 hours to process 12 samples)

Sequencing Data


Data processing


Results
2 PB-level high performance genetic data storage
500TB or 1PB available space for each, scale out to 100PB
Aggregated storage throughput is up to 7GB/s
Automatic data management (local storage or cloud)
No single point of failure, high available design
Optimized storage for genetic data
配合 DNBSEQ-T7 PE150 进行 WFQ 的效率 (每芯片约2T数据量 )
DNBSEQ-T7

Sequencing

ZTRON





Write FASTQ
Data delivery
Data governance
3 Laboratory Information Management System
Full life cycle traceability of samples
Abundant work dashboard, intuitively grasp the production situation
Remote monitoring and early warning of equipment status
Data quality monitoring in sequencing process
Compatible with multiple bioinformatics pipelines


Sample Reception


Sample Preparation


Library Preparation


Sequencing


Bioinformatics Analysis


Report Generation
4 ZMART Application market
100+ tools and applications
Open-source applications, MGI’s self-developed
algorithms and pipelines
Customized pipelines, flexible configurations


Application Scenarios
Scenario 1
collocate with DNBSEQ-T7, output FASTQ files.

DNBSEQ-T7


ZTRON Lite


Customer Data Centre
Scenario 2
collocate with DNBSEQ-T7, output VCF files.

DNBSEQ-T7


ZTRON Pro


Customer Data Centre
Scenario 3
collocate with DNBSEQ-T10RSx4, output FASTQ files.

DNBSEQ-T10x4RS


ZTRON Pro


Customer Data Centre
Scenario 4
collocate with DNBSEQ-T10RSx4, output VCF files.

ZBOLT Pro


DNBSEQ-T10x4RS


ZTRON Pro


Customer Data Centre
Scenario 5
collocate with multiple DNBSEQ-T7, output VCF files.
*If more than 3 T7 sequencers
are connected to ZTRON Pro
Appliance, the customization
is needed.



DNBSEQ-T7 *n






ZTRON Lite *n


ZTRON Pro


Customer Data Centre
Customer Experience
BGI Research
Karolinska Institute
APAC Million Population Genome Project
Product Specifications
ZTRON Lite ZTRON Pro
Form Factor
Tower server
CPU
Intel Xeon Gold 5218R CPU * 2, or with equivalent or better performance
Memory
192GB DDR4
GPU
NVIDIA Quadro RTX4000 or with equivalent or better performance
Data Disk
2.5-inch 3.84TB hot-swappable SSD * 10
OS Disk
480GB non-hot-swappable SSD * 2
RAID Card
Supporting RAID 0, RAID 1, RAID 5 and RAID 6 with super-capacitors
Network
10/25GbE SFP28 dual-port PCIe * 2
Fiber Optic Module
10G multi-mode module * 3 and 10G single-mode module * 1
Power Supply
1,100W 100~240VAC hot-swappable module * 2
Environment
Temperature: 15℃~25℃; Relative Humidity: 20%~80%; for indoor use only
Software
Laboratory information management system, bioinformatics analysis platform and application market
Size
670(length)* 270(width)* 440(depth)
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