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Product Information

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Product Model MGISEQ-T7 MGISEQ-2000 MGISEQ-200 BGISEQ-500 BGISEQ-50
Features Ultra-high Throughput Adaptive Effective Reliable Fast
Applications Whole Genome Sequencing,Deep Exome Sequencing,Transcriptome Sequencing,and Targeted Panel Projects. WGS, WES, Transcriptome sequencing and more Targeted DNA, RNA, Microbial sequencing Targeted DNA, RNA, Epigenetics and clinical applications Pathogen Rapid tests, NIPT, PGS and CNV tests
Lane/Flow Cell++ —— 4 lane 1 lane 2 lane 2 lane
Operation Mode Ultra-high Throughput High Throughput Medium Throughput High Throughput Low Throughput
Max. Throughput / RUN 6Tb 1080Gb 60Gb 520Gb 225Gb
Effective Reads / Flow Cell 5000M 1800M 300M 1300M 375M
Average run time PE150 within 24 hours <48hours <48hours <9days <15hours
Min. Read Length SE50 SE50 SE50 SE50 SE50
Max. Read Length PE150 PE150 PE100 PE100 SE50

MGI gene sequencer core technology

“DNB” – DNA Nano Balls
The key technology to reduce sequencing error rates is known as “DNA Nano Ball (DNB) Technology”.
  • Increasing the quantity of “DNA fragments (to be processed)” through replication increases the intensity of fluorescent signals, which enhances sequencing accuracy;
  • Unlike PCR amplification, amplification errors arising from Rolling Circle Amplification do not accumulate exponentially;
Patterned Array
The array pattern and reference markers are formed on flow cells through a combination of photolithography and dry etching techniques. Aminosilane modification of the exposed silicon surface is undertaken using state-of-the-art semi-conductor precision processing to form precise spots for DNB immobilization to the flow cell.
  • DNB’s and arrayed spots are engineered to enhance attachment of a single DNB to a spot thus preventing cross-talk of signal between DNB’s.
  • The Patterned Array of spots on Flow Cells is designed to maximise resolution of the optical imaging system and the surface area of the flow cell.
Optimised Combinatorial Probe-Anchor Synthesis (cPAS) system
DNA oligonucleotide anchors and fluorescently labelled probes hybridise specifically to the DNB’s; then the high-resolution imaging system captures fluorescent signals which are then digitalised for further processing.
  • Biochemistry team has studied a large quantity of reaction conditions and screened tens of thousands of enzymes to successfully sequence biochemical reactions to complete within just 60 seconds.
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